Pseudoephedrine (PSE) was the most common nasal decongestant found in non-prescription cold products until recently. When the United States Congress recognized the use of pseudoephedrine in the illicit manufacture of methamphetamine, it passed Federal legislation requiring that products containing PSE be placed behind pharmacy counters or in locked boxes to restrict access by September 30, 2006. This was solely intended to help limit the conversion of PSE to methamphetamine (meth) and was in no way due to a concern related to the safety or efficacy of PSE or PSE-containing products.

In response, most manufacturers including Wyeth Consumer Healthcare (makers of Dimetapp®, Robitussin®, and Advil® Cold & Sinus) reformulated their products replacing PSE with phenylephrine (PE). This was intended to keep familiar cold, cough, flu, and allergy symptom relief in a readily-available location in stores for consumers. PE is also a decongestant, and was commonly used prior to the introduction of PSE. PE is also used extensively in Europe and other parts of the world. Both PE and PSE are safe and effective when used as directed, however, PE dosing is different from the dosing for PSE. Please check for new dosing information on all packages before giving new Dimetapp® products to your child.